The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the. Central giant cell granuloma cgcg is a localised benign condition of the jaws. Despite this, a recurrence rate of 1520% is often quoted, and in these cases treatment may need to be more aggressive and may need to consist of an en bloc resection. Central giant cell granuloma cgcg is an uncommon benign bony lesion that occurs in the mandible and maxilla. Central giant cell granuloma is an uncommon, benign, and proliferative lesion whose etiology is not defined. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and peripheral ossifying fibroma. F stavropoulos and j katz central giant cell granulomas. Apr 01, 2002 central giant cell granuloma, a fibro. The clinical behaviour of cgcg ranges from a slowgrowing asymptomatic swelling to an aggressive lesion that presents pain, local bone destruction, root resorption and tooth displacement. It occurs most commonly in mandible, but can also occur in maxilla. Intralesional corticosteroid injection for central giant cell. On the basis of clinical, radiological and histologic features, central giant cell granulomas can be classified as non. The objective was to investigate the clinical and radiological characteristics of central giant cell granulomas cgcgs of the jaws. The clinical, radiological, and histopathological findings of a central giant cell granuloma cgcg arising in the mandible are depicted.
Mar 24, 2020 a central giant cell granuloma is a type of bone lesion that appears along the jaw. Jun 19, 2018 this peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. Surgically treated central giant cell granuloma in six. A retrospective analysis of a 20year database was performed regarding both clinical and radiological features of 22 patients affected with cgcgs of the jaws. Peripheral giant cell granuloma common tumor like growth in the oral cavity. The central giant cell granuloma cgcg was first described by jaffe in 1953 as a giant cell reparative granuloma of the jaw bones. Ct and mr imaging of giant cell granuloma of the craniofacial bones j. Treatment of central giant cell lesions using bisphosphonates. Surgically treated central giant cell granuloma in sixyear. An analysis of peripheral giant cell granuloma associated with dental implant treatment. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings.
The central giant cell granuloma is a tumor that has great potential for the displacement of teeth and the development of a facial deformity. Multinucleated giant cells are a prominent feature of this bone lesion. Conventional management is surgical and consists of enucleation and curettage. Imaging radiolucent destructive lesion with faint trabeculation and loculation. The diagnosis and management of giant cell lesions of the jaws. Files are available under licenses specified on their description page. Cgcg is a relatively uncommon, benign, cystic, intraosseous lesion that was first described in 1953. Pdf the central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in. Mar 21, 2012 central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Interventions for central giant cell granuloma of the jaws.
Central giant cell lesion cgcl is a benign lesion which has unpredictable biologic behaviour and is amenable to a plethora of treatment alternatives. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs almost exclusively in the mandible, although cases in the skull and maxilla have been reported. Peripheral giant cell granuloma in a child associated with. Peripheral and central giant cell granulomas of the jaws. Peripheral giant cell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Extremely aggressive behavior of central giant cell granuloma. This report describes the clinical and histopathological findings of a pgcg diagnosed in the maxilla of a 9yearold boy associated with a tooth erupting improperly and a. Does not represent a true neoplasm but a reactive lesion.
Often called as peripheral giant cell reparative granuloma. A clinical, radiologic and histopathologic study of 26 cases ooo 2006. Aggressive central giant cell granuloma of the mandible, a. Radiographs of a biopsyproven central giant cell granuloma of the left anterior mandible in a 23yearold female a represents the lesion at the time of biopsy and b represents the lesion some 18 months later. We describe our experience in managing this lesion by intralesional triamci. The central giant cell granuloma is a relatively common lesion of the jaws. All structured data from the file and property namespaces is available under the creative commons cc0 license. Central giant cell granuloma, australian endodontic journal. Interventions for central giant cell granuloma cgcg of the. The central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. Although relatively common in the dentate mandible, only 5 cases of central giant cell granuloma in the mandibular condyle have so far been reported. The central giant cell granuloma is a benign and sometimes aggressive osteolytic proliferation. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad.
Its etiology is unknown and its biological behavior is poorly understood. The lesion, which has a greater incidence in females, may be uni or multilocular. Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections. We report a case of a large central giant cell granuloma of the condylar head with extension into the infratemporal fossa in a 29yearold male. Central giant cell granuloma venkateshwarlu et, al 6. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Oral surg oral med oral pathol oral radiol endod, 2007. The case report is of a 30 year old male, who complained of a slowly expanding swelling in the maxilla in the left premolar region. An osteodestructive lesion of uncertain pathogenesis, which most commonly occurs in the young female mandible, and is more lytic than peripheral giant cell granuloma. Central giant cell granuloma is an uncommon benign proliferative lesion that almost exclusively occurs within the jaw. The referring doctor had suggested a diagnosis of eruption cyst. Apr 17, 2015 central giant cell granuloma was 1st described in jaws by jaffe 1953.
Like pyogenic granuloma and peripheral ossifying fibroma, peripheral giant cell granuloma may represent an unusual response to tissue injury. Giant cell reparative granuloma, central definition of. The central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas. Central giant cell granuloma of the mandibular condyle. It is distinguishable from pyogenic granuloma and peripheral ossifying fibroma only on the basis of its unique histomorphology, which is the same as central giant cell granuloma 8, 9. This is a temporary file and hence do not link it from a website, instead link the url of this page if you wish to link the pdf file. Eventually, it may become aggressive leading to the expansion and perforation of cortex resulting into mobility and displacement of teeth with root resorption. Aggressive central giant cell granuloma of the mandible, a diagnostic dilemma. This article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology.
We herein describe an intriguing case of a 21yearold male patient who was. Central giant cell lesions granuloma radiology reference. Ct and mr imaging of giant cell granuloma of the craniofacial. This condition is a slowgrowing, asymptomatic lesion that usually affects children and young adults, predominantly females. It is twice as common in females and is more likely to occur before age 30.
Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. Central giant cell granuloma is an uncommon benign proliferative lesion occurring more commonly in the anterior mandible. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. The case described here involved maxilla which was treated with surgical excision. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the craniofacial bones. Diffdx giant cell bone tumour, pthinduced brown tumour. It is a noncancerous condition that is usually painless, but irritation and open lesions in the mouth can lead to an infection and uncomfortable swelling. These tumors become severely invasive with the stimulus of surgery, resembling malignant tumors. It may become aggressive leading to expansion and perforation of the cortex. Peripheral giant cell granuloma pgcg is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely occurring in children. This article is from international journal of clinical pediatric dentistry, volume 6. Casereport munzenmayer j1, tapia p2, zeballos j2, martinez a3, compan a4, urra a5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection and reconstruction with fibula graft. Although central giant cell granulomas cgcgs appear to be benign, their radiographic findings are active. Abstractcentral giant cell granuloma cgcg is a benign intraosseous.